EN
FR
Search for:
Navigation
Services
Preclinical
Clinical
Biotesting
Regulatory
Home
About us
The company
The executive team
The facilities
Our partners
Certifications
Jobs
News & Events
News & Publications
Events
Testimonials
FAQ
Contact
News & Events
>
News & Publications
>
Associations of urinary Coll2-1NO2 with knee OA
Associations of urinary biomarker COLL2-1NO2 with incident clinical and radiographic knee OA in overweight and obese women
Published on 17/04/2015
Associations of urinary Coll2-1NO2 with knee OA
OBJECTIVE:
To investigate the association between urinary biomarker Coll2-1NO2 (uColl2-1NO2) and incident knee OA after 2.5 years follow-up in middle-aged overweight and obese women at high risk for knee osteoarthritis (OA).
DESIGN:
Data were used from PROOF, a randomized controlled trial with 2.5 years follow-up evaluating the preventive effects of a diet and exercise program and oral glucosamine sulphate (double blind and placebo controlled), on development of incident knee OA in women with body mass index ≥ 27 kg/m2 without signs of knee OA at baseline. Baseline and 2.5 years uColl2-1NO2 concentrations were assessed with enzyme-linked immunosorbent assay (ELISA). Primary outcome measure was incidence of knee OA in one or both knees, defined as incidence of either Kellgren & Lawrence grade ≥2, joint space narrowing of ≥1.0 mm or knee OA according to the combined clinical and radiographic ACR-criteria. We used binary logistic regression for the association analyses.
RESULTS:
254 women were available for analyses. At 2.5 years follow-up, incident knee OA was present in 72 of 254 women (28.3%). An inversed association was found between baseline uColl2-1NO2 and incident knee OA at 2.5 years (OR 0.74, 95% CI 0.55-0.99). The concentration at 2.5 years and the change in concentration over 2.5 years did not show significant associations with the outcome.
CONCLUSIONS:
In overweight and obese middle-aged women, not higher but lower baseline uColl2-1NO2 concentration was significantly associated with an increased risk for incident knee OA. This interesting but counterintuitive outcome makes further validation of this biomarker warranted.
PubMed
Our latest news
11/05/2023
Heeft u artrose van de knie?
03/05/2023
Klinisch onderzoek naar spierzwakte
Read more
News & Publications
Events
Testimonials
© Artialis - All rights reserved
Cookie Notice
-
Privacy Policy
Made by